Benefiting from CTLA-4 blockade—a genetic rationale
نویسندگان
چکیده
منابع مشابه
CTLA-4: From conflict to clinic
CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. Uncertainties about its biological function plagued the early years after its discovery until 1995, when it was confirmed to be an inhibitor of T cell responses. CTLA-4 has since scored in the clinic as a target for antitumor therapy and as a soluble inhibitor of autoimmunity.
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2014
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2014.217